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Human CellExp™ ACE2, Human Recombinant

Carboxypeptidase which converts angiotensin I to angiotensin 1-9
Catalog #: P1535
SKU-Size Size Price Qty
P1535-10 10 μg
$125.00
P1535-50 50 μg
$495.00
More Sizes Get Quote

Product Details

Alternate Name Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-Converting Enzyme Homolog, ACEH, Metalloprotease MPROT15, ACE2
Gene Symbol ACE2
Gene ID 59272
Accession # Q9BYF1
Source HEK 293 Cells
Appearance Liquid protein
Physical Form Description Liquid
Molecular Weight 84 kDa (N-terminal 6x His-tag)
Purity by >95%
Biological Activity Fig. B. Biological activity: The specific activity is >1 U/mg which was assayed using BioVision’s Angiotensin II Converting Enzyme (ACE2) Activity Assay Kit (Fluorometric, Catalog # K897).
Amino Acid Sequence aa Gln 18 - Ser 740
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Angiotensin converting enzyme 2 (ACE2) is a receptor for SARS-CoV and SARS-CoV-2 (the virus causing coronavirus disease 2019, COVID-19). The spike protein of SARS-CoV recognizes ACE2 as its receptor during the first step in viral entry. ACE2 converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, a vasodilator. It cleaves other biological peptides, such as apelins, casomorphins and dynorphin A with high efficiency. Antibodies targeting ACE2 and spike protein receptor binding domain (RBD) interaction could be used to block SARS-CoV-2 viral entry thereby suppress virus replication.


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