Product Details
| Cat # +Size | 7232-10 |
|---|---|
| Size | 10 μg |
| Alternate Name | ADIPOQ, Adiponectin, ACDC, ACRP30, APM1, GBP28 |
| Gene Symbol | ADIPOQ |
| Gene ID | 9370 |
| Accession # | Q15848 |
| Source | HEK 293 cells |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH7.4. |
| Molecular Weight | The protein is fused with 6×His tag at the C-terminus, has a calculated MW of 25.4 kDa |
| Purity by SDS-PAGE | ≥95% |
| Endotoxin Level | < 0.1 ng/μg of protein (<1EU/μg). |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Adiponectin also referred to as GBP-28, APM1, ADIPOQ, ACDC and Acrp30, is a secreted protein which contains one C1q domain (commonly called the globular domain) and one collagen-like domain. Adiponectin / ADIPOQ is synthesized exclusively by adipocytes and secreted into plasma. ADIPOQ is important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Acrp30 Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway and may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
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