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Human CellExp™ Active Transmembrane Serine Protease 2 (TMPRSS2), Human Recombinant

A biomarker in prostate cancer and a point of cell entry for SARS-CoV-2
Catalog #: P1680
SKU-Size Size Price Qty
P1680-10 10 µg
$175.00
P1680-50 50 µg
$415.00
More Sizes Get Quote

Product Details

Alternate Name Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin
Gene ID 7113
Accession # O15393
Source HEK 293 cells
Appearance Sterile Filtered colorless solution
Physical Form Description Liquid
Molecular Weight 44.8 kDa (8xHis tag at the C-terminus)
Purity by SDS-PAGE > 95%
Formulation PBS pH 7.4 with 50% glycerol
Amino Acid Sequence Trp 106 – Gly 492 (with a substitution at R255Q)
Specific Activity The specific activity is > 50 µU/mg which was assayed using BioVision’s TMPRSS2 Inhibitor Screening Kit (Fluorometric) (Cat.No. K2113).
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The transmembrane serine protease 2 (TMPRSS2) plays an important role in the infection mechanism of human coronaviruses such as SARS-CoV-2. Cell entry of SARS-CoV-2 depends on the binding of the viral spike (S) glycoprotein to the ACE2 receptor and S protein priming by TMPRSS2. The protease domain of TMPRSS2 is also theorized to be cleaved and secreted extracellularly after autocleavage. Additionally, TMPRSS2 is shown to be upregulated by androgen in prostate cancer cells and downregulated in androgen-independent prostate cancer.


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