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Human CellExp™ Acetylcholinesterase / AChE, Human Recombinant

Catalog #: P1475
SKU-Size Size Price Qty
P1475-10 10 µg
$275.00
P1475-50 50 µg
$825.00
More Sizes Get Quote

Product Details

Alternate Name Acetylcholinesterase (EC:3.1.1.7), AChE
Gene Symbol ACHE
Gene ID 43
Accession # P22303
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight ~70 kDa (C terminal 6×His tag)
Purity by SDS-PAGE >95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence Glu 32 – Leu 614
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline in both central and peripheral nervous systems. Mild inhibition of AChE has been shown to have therapeutic relevance in Alzheimer's disease (AD), myasthenia gravis, and glaucoma among others. In contrast, strong inhibition of AChE can lead to cholinergic poisoning. An irregular expression of AChE has also been found in different types of tumors, suggesting the involvement of AChE in the regulation of tumor development. Therefore AChE inhibitors could potentially be used in cancer treatment in the future.


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