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Human CellExp™ ACE1, Human Recombinant

Human cell expressed human recombinant ACE1 protein
Catalog #: P1660
SKU-Size Size Price Qty
P1660-10 10 μg
$195.00
P1660-50 50 μg
$695.00
More Sizes Get Quote

Product Details

Alternate Name Human CellExp™ ACE1, Human Recombinant; Angiotensin-Converting Enzyme, ACE1, ACE, CD antigen CD143, DCP1, DCP, Dipeptidyl carboxypeptidase I, Kininase II, Peptidyl-dipeptidase A, Peptidyldipeptide Hydrolase, EC 3.4.15.1, UniProtKB - P12821; ACE1, Human Recombinant; Human Recombinant ACE1; Human Cell Expressed ACE1, Human Recombinant; ACE 1
Accession # P12821
Source HEK 293 cells
Appearance Liquid
Physical Form Description Liquid
Molecular Weight 170 kDa (His-tag at the C-terminus)
Purity by SDS-PAGE ≥ 95%
Biological Activity The specific activity is > 200 U/mg, assayed using BioVision’s Angiotensin I Converting Enzyme Activity (ACE1) Assay Kit (Fluorometric) (BV Cat # K227-100).
Amino Acid Sequence 30-1232
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The angiotensin 1 converting enzyme (ACE1) is a zinc metalloproteinase. It functions as a central component of the well acknowledged renin–angiotensin system (RAS), where ACE plays an important physiological role in regulation of blood pressure via the conversion of angiotensin I to angiotensin II. Inhibition of ACE has been a targeted therapeutic strategy for treating hypertension. ACE can be specifically inhibited by peptide like lisinopril, captopril and enalaprilat. ACE is also crucial for fertilization for releasing the proteins anchored to glycosylphosphatidylinositol (GPI) in sperm membrane. Germinal angiotensin-converting enzyme (gACE) was shown to be undetectable in sperm from patients with fertilization failure. ACE1 and its homologue, ACE2, have been mostly associated with hypertension disorders. SARS-CoV-2 virus has been shown to exploit ACE2 protein to enter cells. The differences in the course of SARS-CoV-2 infection have been attributed to difference in expression levels and function of ACE proteins.


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