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Human CellExp™ ABP1/AOC1, Human Recombinant

Catalyzes the oxidation of biogenic amines
Catalog #: P1558
SKU-Size Size Price Qty
P1558-10 10 μg
$105.00
P1558-50 50 μg
$495.00
More Sizes Get Quote

Product Details

Alternate Name Amiloride-sensitive amine oxidase, DAO, Diamine oxidase, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, Histaminase, Kidney amine oxidase, KAO, ABP, ABP1, DAO1
Gene Symbol AOC1
Gene ID 26
Accession # P19801
Source HEK 293 cells
Appearance Sterile Filtered colorless solution
Physical Form Description Liquid
Molecular Weight 84.2 kDa (6 x His tag at C terminal)
Purity by SDS-PAGE >90%
Endotoxin Level < 1 EU per 1ug of protein (determined by LAL method)
Amino Acid Sequence 738 aa (aa 20-751)
Handling Centrifuge the vial prior to opening.
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ABP1, also known as diamine oxidase (DAO) and amine oxidase copper domain-containing protein 1 (AOC1), is a member of the copper-containing amine oxidase family. This enzyme catalyzes the oxidation of a wide range of biogenic amines including many neurotransmitters, histamine and xenobiotic amines. It has an important role in the catabolism of histamine and other bioactive polyamines. Deficiencies in ABP1 can result in histaminosis or dietary histamine intolerance. This protein is also contributed to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer. Recombinant human AOC1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.


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