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Human CellExp™ 4-1BB / TNFRSF9, Human recombinant

A transmembrane cytokine 
Catalog #: 9227
SKU-Size Size Price Qty
9227-10 10 µg
$200.00
9227-50 50 µg
$610.00
More Sizes Get Quote

Product Details

Alternate Name TNFRSF9,4-1BB,CD137,CDw137,ILA
Gene Symbol TNFRSF9
Gene ID 3604
Accession # NP_001552.2
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Molecular Weight This protein is fused with a 6× His tag at C-terminus and has a calculated MW of 18.1 kDa. The protein migrates as 28-35 kDa in SDS-PAGE due to glycosylation.
Purity by SDS-PAGE ≥92%
Purity by ≥92%
Endotoxin Level < 1 EU/μg
Biological Activity Immobilized Human 4-1BB, His Tag at 100 ng/Ml (100 µl/well),can bind Human 4-1BB Ligand, Fc Tag with a linear of 0.1-2.5 ng/mL.
Reconstitution Instructions Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF.responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF


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