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Human Beta-Catenin

A component of the Wnt signalling pathway
Catalog #: P1626
SKU-Size Size Price Qty
P1626-20 20 μg
$195.00
P1626-50 50 μg
$375.00
More Sizes Get Quote

Product Details

Alternate Name Catenin beta-1; CTNNB1; CTNNB
Gene ID 1499
Accession # P35222-1, XP_016861227.1
Source E.coli
Appearance Liquid
Molecular Weight The protein migrates as a ~100-110 kDa band in SDS-PAGE.
Purity by SDS-PAGE ≥ 92%
Endotoxin Level < 0.1 EU/μg of the protein as determined by LAL method
Amino Acid Sequence The target protein is expressed with the sequence (aa Met1-Leu781) of human Beta-Catenin protein fused to 6×His tag at the C-terminus.
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.

Details

Beta-catenin is a key downstream component of the canonical Wnt signaling pathway. β-catenin associates with E-cadherin and is involved in regulation of cell adhesion. Stimulation of Wnt pathway can trigger nuclear translocation of β‐catenin. Over expression of β-catenin occurs in various cancers such as colorectal, lung, malignant breast tumor, hepatocellular carcinoma and can be used as a tumor biomarker.


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