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Product Details
| Alternate Name | Catenin beta-1; CTNNB1; CTNNB |
|---|---|
| Gene ID | 1499 |
| Accession # | P35222-1, XP_016861227.1 |
| Source | E.coli |
| Appearance | Liquid |
| Molecular Weight | The protein migrates as a ~100-110 kDa band in SDS-PAGE. |
| Purity by SDS-PAGE | ≥ 92% |
| Endotoxin Level | < 0.1 EU/μg of the protein as determined by LAL method |
| Amino Acid Sequence | The target protein is expressed with the sequence (aa Met1-Leu781) of human Beta-Catenin protein fused to 6×His tag at the C-terminus. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Beta-catenin is a key downstream component of the canonical Wnt signaling pathway. β-catenin associates with E-cadherin and is involved in regulation of cell adhesion. Stimulation of Wnt pathway can trigger nuclear translocation of β‐catenin. Over expression of β-catenin occurs in various cancers such as colorectal, lung, malignant breast tumor, hepatocellular carcinoma and can be used as a tumor biomarker.
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