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HTH-01-015

A potent and selective inhibitor of NUAK1 kinase
Catalog #: 2887
SKU-Size Size Price Qty
2887-5 5 mg
$165.00
2887-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name 4,5,13-trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6(13H)-one
Appearance Crystalline solid
CAS # 1613724-42-7
Molecular Formula C₂₆H₂₈N₈O
Molecular Weight 468.55
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1=C2C(=NC(=N1)NC3=CN(N=C3)C4CCNCC4)N(C5=CC6=CC=CC=C6C=C5C(=O)N2C)C
InChi nChI=1S/C26H28N8O/c1-16-23-24(31-26(29-16)30-19-14-28-34(15-19)20-8-10-27-11-9-20)32(2)22-13-18-7-5-4-6-17(18)12-21(22)25(35)33(23)3/h4-7,12-15,20,27H,8-11H2,1-3H3,(H,29,30,31)
InChi Key CHSDJDLAKKAWCI-UHFFFAOYSA-N
PubChem CID 78357766
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

HTH-01-015 is a potent and selective inhibitor of NUAK1 kinase (IC₅₀ =100 nM); only weakly inhibits NUAK2 (IC₅₀ of >10 μM) and does not significantly inhibit the activity of 139 other kinases that were tested including ten AMPK family members.


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