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HSP70 antibody

Catalog #: 5859
SKU-Size Size Price Qty
5859-30T 30 µg
$89.00
5859-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target HSP70
Alternate Name HSP70 antibody, anti-HSP70, anti HSP70, heat shock protein 70 antibody,polyclonal HSP70 antibody, HSP70, HSP-70, HSP 70, HSP, heat shock protein
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen E. coli-expressed recombinant human HSP70
Accession # P08107
Gene ID 3033/ 3034
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 30 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot
Positive Control Recombinant human HSP70 (Cat.# 4859-25)
Application & Usage The antibody can be used in Western Blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human HSP70 (Cat.# 4859-25) can be used as a positive control
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

HSP70 is a class of highly conserved stress proteins. HSP70 is comprised of multiple members, all of which bind ATP in vitro, but are localized within different intracellular compartments. These include: a) the constitutive Hsc70 (or cognate) present within the cytosol/nucleus; b) the highly stress-inducible HSP70 present within the cytosol/ nucleus/nucleolus; c) the constitutive glucose regulated 78 kDa (or BiP) protein present within the lumen of the endoplasmic reticulum; and d) the glucose regulated 75 kDa protein present within the mitochondria. HSP70 is typically not expressed in the cell under normal growth conditions, but is expressed at high levels in the cell experiencing stress. Therefore, detection of HSP70 using an antibody specific for the inducible form is quite useful in ascertaining whether a stress response has occurred in the cell.


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