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A potent RIP3 kinase inhibitor
Catalog #: B2430

In stock

SKU-Size Size Price Qty
B2430-5 5 mg
B2430-25 25 mg
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Product Details

Alternate Name 4-(4-methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline, HS1371, EX-A2073
Appearance Crystalline solid
CAS # 2158197-70-5
Molecular Formula C₂₄H₂₄N₂₄O
Molecular Weight 384.47
Purity ≥98% by HPLC
Solubility >10 mg/ml in DMSO
InChi InChI=1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
PubChem CID 134817449
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


HS-1371 is a potent RIP3 kinase inhibitor (IC₅₀ = 20.8 nM). It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro. . It inhibits TNF-induced necroptosis but does not inhibit TNF-induced apoptosis, indicating that HS-1371 has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.

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