Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


A potent inhibitor of HDAC6
Catalog #: B2832
SKU-Size Size Price Qty
B2832-1 1 mg
B2832-5 5 mg
More Sizes Get Quote

Product Details

Alternate Name N-hydroxy-4-[2-[N-(2-hydroxyethyl)anilino]-2-oxoethyl]benzamide; 4-[2-[2-Hydroxyethyl(Phenyl)amino]-2-Oxidanylidene-Ethyl]-~{n}-Oxidanyl-Benzamide; 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenylbenzeneacetamide
Appearance Crystalline solid
CAS # 1429651-50-2
Molecular Formula C₁₇H₁₈N₂O₄
Molecular Weight 314.34
Purity ≥95%
Solubility ~10 mg/ml in DMF
~15 mg/ml in Ethanol
~20 mg/ml in DMSO
InChi InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22)
PubChem CID 71532921
MDL Number MFCD27952937
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


HPOB is a hydroxamic acid-based small-molecule that selectively inhibits histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of recombinant HDAC6 is 56 nM. It inhibits the growth of normal human foreskin fibroblast (HFS) and transformed (LNCaP, human prostate adenocarcinoma, A549 lung adenocarcinoma, and U87 glioblastoma) cells in a concentration-dependent manner at 8 μM, 16 μM, or 32 μM, but does not induce cell death. HPOB causes accumulation of acetylated α-tubulin in these cells. HPOB enhances cell death induced by the anticancer drugs etoposide, doxorubicin and SAHA.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.