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HPOB

A potent inhibitor of HDAC6
Catalog #: B2832
SKU-Size Size Price Qty
B2832-1 1 mg
$65.00
B2832-5 5 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name N-hydroxy-4-[2-[N-(2-hydroxyethyl)anilino]-2-oxoethyl]benzamide; 4-[2-[2-Hydroxyethyl(Phenyl)amino]-2-Oxidanylidene-Ethyl]-~{n}-Oxidanyl-Benzamide; 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenylbenzeneacetamide
Appearance Crystalline solid
CAS # 1429651-50-2
Molecular Formula C₁₇H₁₈N₂O₄
Molecular Weight 314.34
Purity ≥95%
Solubility ~10 mg/ml in DMF
~15 mg/ml in Ethanol
~20 mg/ml in DMSO
SMILES C1=CC=C(C=C1)N(CCO)C(=O)CC2=CC=C(C=C2)C(=O)NO
InChi InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22)
InChi Key RFAZNTABYJYOAR-UHFFFAOYSA-N
PubChem CID 71532921
MDL Number MFCD27952937
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

HPOB is a hydroxamic acid-based small-molecule that selectively inhibits histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of recombinant HDAC6 is 56 nM. It inhibits the growth of normal human foreskin fibroblast (HFS) and transformed (LNCaP, human prostate adenocarcinoma, A549 lung adenocarcinoma, and U87 glioblastoma) cells in a concentration-dependent manner at 8 μM, 16 μM, or 32 μM, but does not induce cell death. HPOB causes accumulation of acetylated α-tubulin in these cells. HPOB enhances cell death induced by the anticancer drugs etoposide, doxorubicin and SAHA.


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