A potent Hedgehog signaling pathway inhibitor
Catalog #: 2410 | abID:

Product Details

Alternate Name 2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate
Appearance Yellow solid
CAS # 599150-20-6
Molecular Formula C₂₇H₂₉NO₆ · XH₂O
Molecular Weight 463.52
Purity ≥98% by TLC
Solubility DMSO (~25 mg/ml) or EtOH (~25 mg/ml)
InChi InChI=1S/C27H29NO6.H2O/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20-9-4-5-10-23(20)33-3;/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3;1H2
PubChem CID 71311904
MDL Number MFCD17215941
Handling Protect from light and air
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC₅₀’s range from 0.2 to 6 µM for various cell-based assays

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