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HNHA

An inhibitor of HDAC
Catalog #: B2821
SKU-Size Size Price Qty
B2821-1 1 mg
$65.00
B2821-5 5 mg
$245.00
More Sizes Get Quote

Product Details

Alternate Name N-hydroxy-7-naphthalen-2-ylsulfanylheptanamide, Histone deacetylase inhibitor VI, N-hydroxy-7-(2-naphthalenylthio)-heptanamide
Appearance Crystalline solid
CAS # 926908-04-5
Molecular Formula C₁₇H₂₁NO₂S
Molecular Weight 303.42
Purity ≥98%
Solubility ~20 mg/ml in ethanol, DMSO and DMF
SMILES C1=CC=C2C=C(C=CC2=C1)SCCCCCCC(=O)NO
InChi InChI=1S/C17H21NO2S/c19-17(18-20)9-3-1-2-6-12-21-16-11-10-14-7-4-5-8-15(14)13-16/h4-5,7-8,10-11,13,20H,1-3,6,9,12H2,(H,18,19)
InChi Key KPNNXHVGOKRBEF-UHFFFAOYSA-N
PubChem CID 16126782
MDL Number MFCD10568146
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

HNHA is an inhibitor of Histone deacetylase (HDAC). It inhibited proliferation of HT1080 human fibrosarcoma cells with an IC₅₀ of 7.5 μM. It induced hyperacetylation, upregulation of p21 transcription and cell cycle arrest. It inhibited the growth of tumor tissue in a mouse model.


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