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Anti-HMGB1 Antibody

Polyclonal Antibody to detect HMGB1 in Human, mouse and rat samples
Catalog #: A1005
$350.00

Product Details

Cat # +Size A1005-50
Size 50 µl
Antibody Target HMGB1
Alternate Name High mobility group protein B1, High mobility group protein 1, HMG-1, HMG3, SBP-1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant protein of human HMGB1
Accession # P09429
Gene ID 3146
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 50 µl purified antibody supplied in PBS containing 50% glycerol and 0.02% sodium azide
Purification Affinity purified rabbit IgG
Species Reactivity Human, mouse, rat
Application Western Blot, Immunohistochemistry, Immunofluorescence
Positive Control Western blot
Application & Usage WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance.


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