A positive modulator of the Wnt/β-catenin pathway
Catalog #: B3349 | abID:

Product Details

Alternate Name 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
Appearance Solid
CAS # 854847-61-3
Molecular Formula C₁₇H₁₇NO₂
Molecular Weight 267.3
Purity 98%
Solubility ~2 mg/ml DMSO
InChi InChI=1S/C17H17NO2/c1-3-11-5-4-6-13-14-8-16-15(19-10-20-16)7-12(14)9-18(2)17(11)13/h4-8H,3,9-10H2,1-2H3
PubChem CID 104981
MDL Number MFCD00011921
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


HLY78 is a positive modulator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. HLY78 activates Wnt signaling in vivo, altering Wnt-dependent gene expression and embryonic development in zebrafish.

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