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HLCL-61 hydrochloride

A selective PRMT5(potent arginine methyltransferase 5) inhibitor
Catalog #: B1209
SKU-Size Size Price Qty
B1209-5 5 mg
$115.00
B1209-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
Appearance Crystalline Solid
CAS # 586395-74-6 (free base). 
Molecular Formula C₂₃H₂₅ClN₂O 
Molecular Weight 380.92
Purity ≥98% by HPLC
Solubility DMSO(>20 mg/ml)
SMILES CN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=CC=CC=C41.Cl
InChi InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
InChi Key XYAVCNMZZKTEGR-UHFFFAOYSA-N
PubChem CID 17208222
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

HLCL-61 is a potent and selective PRMT5 (potent arginine methyltransferase 5) inhibitor. It shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members.  In vitro data shows HLCL-61 effectively inhibits symmetric arginine demethylation of histones H3 and H4 in AML samples. HLCL-61 treatment of cells showed decrease in cell vitality and effective in apoptosis promotion in MV-11 and THP-1 cells after 48 hours.


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