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HLA-B Antibody (Clone # 7G7F9)

Monoclonal Antibody to detect HLA B in human samples.
Catalog #: 6791
$245.00

Product Details

Cat # +Size 6791-100
Size 100 μl
Antibody Target HLA-B
Alternate Name HLA-B; HLAB; HLA class I histocompatibility antigen, B-27 alpha chain; MHC class I antigen B*27
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgM
Immunogen This HLA-B antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from human HLA-B.
Accession # P30493
Gene ID N/A
Appearance Colorless liquid
Formulation This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Purification Euglobin precipitation followed by dialysis against PBS.
Species Reactivity Human.
Application Western blot.
Positive Control Western blot: Ramos cell lysate.
Application & Usage WB: 1:100 – 1:250.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind peptides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-B and HLA-C encode membrane anchored heavy chains which heterodimerize with a light chain (∫-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-B and HLA-C alleles.


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