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Product Details
| Cat # +Size | 6790-50 |
|---|---|
| Size | 50 μl |
| Antibody Target | HLA-A |
| Alternate Name | HLA-A; HLAA; HLA class I histocompatibility antigen, A-3 alpha chain; MHC class I antigen A*3 |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse IgG1, 2bk |
| Immunogen | This HLA-A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 70-99 amino acids from human HLA-A. |
| Accession # | P05534 |
| Gene ID | N/A |
| Appearance | Colorless liquid |
| Formulation | Crude ascites with 0.09% (W/V) sodium azide. |
| Purification | Protein G purification followed by dialysis against PBS |
| Species Reactivity | Human, Mouse. |
| Application | Western blot. |
| Positive Control | Western blot: Ramos cell lysate. |
| Application & Usage | WB: 1:500 – 1:1000. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind peptides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-A encodes a membrane anchored heavy chain which hetero-dimerizes with a light chain (b-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-A alleles.
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