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Histone H4 (1-103 aa), Human recombinant

Core component of nucleosome
Catalog #: 7671
SKU-Size Size Price Qty
7671-100 100 μg
$165.00
7671-250 250 μg
$365.00
More Sizes Get Quote

Product Details

Alternate Name Histone H4, H4
Gene Symbol HIST1H4A
Gene ID 8359
Accession # P62805
Source E. coli
Appearance Liquid
Physical Form Description Supplied in water
Molecular Weight 11.5 kDa (1-103 aa)
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Resuspend in buffer of choice.
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

H2A is a core component of nucleosome. A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around an octamer of histones. The octamer is composed of two of each histone H2A, H2B, H3, and H4. DNA accessibility is regulated via a complex set of post-translational modifications of these histones, also called histone code, and nucleosome remodeling. Histones H2A and H2B form a dimer. Histones H3 and H4 form a tetramer. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Histone H4 undergoes many modifications which include acetylation, phosphorylation and methylation that are important for regulation of gene transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.


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