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Histone H3 (Citrullinated R2, R8, R17) Antibody

A potential autoimmune disease biomarker
Catalog #: A2318
SKU-Size Size Price Qty
A2318-50 50 µl
$195.00
A2318-100 100 µl
$325.00
More Sizes Get Quote

Product Details

Antibody Target Citrullinated Human Histone H3
Alternate Name Histone H3; H3 Clustered Histone 1; H3/A; Histone H3.1; Histone H3/A
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Histone H3 peptide citrullinated at R2, R8, and R17
Accession # P64831
Gene ID 8350
Appearance Liquid
Formulation TBS, pH 7.4, with 50% glycerol, 0.1% BSA, 0.02% sodium azide
Purification Peptide affinity purification
Species Reactivity Human
Application ELISA, Western Blotting
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Histone H3 is a nuclear protein that is a component of the histone complex that is essential for the organization of genetic material in eukaryotes. Histone H3 can be citrullinated by protein argine deiminase 4 (PAD4) at positions 2, 8, and 17, which blocks methylation and induces transcriptional repression at target genes. The citrullinated histone H3 is found in neutrophil extracellular traps (NETs), which act to induce production of autoantibodies associated with various diseases such as multiple sclerosis and rheumatoid arthritis.


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