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Histone H2B (1-123 aa), Xenopus recombinant

Core component of nucleosome
Catalog #: 7669
SKU-Size Size Price Qty
7669-100 100 μg
$165.00
7669-250 250 μg
$365.00
More Sizes Get Quote

Product Details

Alternate Name H2B, Histone H2B type 1-A, HIST1H2BA, TSH2B
Source E. coli
Appearance Lyophilized powder
Physical Form Description Lyophilized powder. Recommended buffer is 50 mM sodium phosphate, pH 7.2, containing 300 mM sodium chloride, 1 mM DTT, 1 mM EDTA and 20% glycerol.
Molecular Weight 13.7 kDa (1-123 aa)
Purity by SDS-PAGE ≥90%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

H2A is a core component of nucleosome. A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around an octamer of histones. The octamer is composed of two of each histone H2A, H2B, H3, and H4. DNA accessibility is regulated via a complex set of post-translational modifications of these histones, also called histone code, and nucleosome remodeling. Histones H2A and H2B form a dimer. Histones H3 and H4 form a tetramer. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Histone H2B undergoes many modifications which include acetylation, phosphorylation, ubiquitylation, sumoylation, and biotinylation that are important for regulation of gene transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.


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