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HG-10-012-01

A wild-type LRRK2 and the G2019S mutant inhibitor
Catalog #: 2604
SKU-Size Size Price Qty
2604-5 5 mg
$125.00
2604-25 25 mg
$485.00
More Sizes Get Quote

Product Details

Alternate Name [4-[[5-Chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone
Appearance White to off-white solid
CAS # 1351758-81-0
Molecular Formula C₁₇H₂₀ClN₅O₃
Molecular Weight 377.83
Purity >98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES O=C(N1CCOCC1)C(C=C2)=CC(OC)=C2NC3=NC=C(Cl)C(NC)=N3
InChi InChI=1S/C17H20ClN5O3/c1-19-15-12(18)10-20-17(22-15)21-13-4-3-11(9-14(13)25-2)16(24)23-5-7-26-8-6-23/h3-4,9-10H,5-8H2,1-2H3,(H2,19,20,21,22)
InChi Key YEVOZZZLKJKCCD-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Brain-permeable. HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant (IC₅₀ values are ~20.3 nM and ~ 3.2 nM, respectively). It significantly inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells. May be a useful tool for Parkinson’s Disease research.


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