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JNJ-7706621

A potent inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases
Catalog #: B1941

In stock

SKU-Size Size Price Qty
B1941-1 1 mg
$85.00
B1941-5 5 mg
$335.00

Product Details

Alternate Name 4-[[5-amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
Appearance Crystalline solid
CAS # 443797-96-4
Molecular Formula C₁₅H₁₂F₂N₆O₃S
Molecular Weight 394.36
Purity ≥98% by HPLC
Solubility DMSO (>18 mg/ml)
SMILES C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F
InChi InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
InChi Key KDKUVYLMPJIGKA-UHFFFAOYSA-N
PubChem CID 5330790
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

JNJ-7706621 is a potent inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases with IC₅₀ values of 9 nM, 4 nM, 11 nM and 15 nM for CDK1, 2 and Aurora A, B, respectively. In vitro assays shows that JNJ-7706621 inhibits glioblastoma cellular viability, proliferation, and migration via inducing glioblastoma cells apoptosis.


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