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Hesperadin

A potent, ATP-competitive inhibitor of Aurora B kinase
Catalog #: B1940

In stock

SKU-Size Size Price Qty
B1940-5 5 mg
$185.00
B1940-25 25 mg
$725.00

Product Details

Alternate Name N-[(3Z)-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anilino]methylidene]-1H-indol-5-yl]ethanesulfonamide
Appearance Crystalline solid
CAS # 422513-13-1
Molecular Formula C₂₉H₃₂N₄O₃S
Molecular Weight 516.65
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml)
SMILES CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=O)C2=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN5CCCCC5
InChi InChI=1S/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,30,32H,2,4,7-8,17-18,20H2,1H3,(H,31,34)/b28-27-
InChi Key GLDSKRNGVVYJAB-DQSJHHFOSA-N
PubChem CID 10142586
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Hesperadin is a potent, ATP-competitive inhibitor of Aurora B kinase (IC₅₀ = 250 nM). Hesperadin inhibits Aurora B kinase by phosphorylation of histone H3. Also acts as a broad-spectrum influenza antiviral agent.


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