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HER2, Active, Human Recombinant

Active, Human Recombinant Her2 for functional assays.
Catalog #: 8011

In stock

SKU-Size Size Price Qty
8011-5 5 µg
$175.00
8011-50 50 µg
$995.00
More Sizes Get Quote

Product Details

Alternate Name HER, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Gene Symbol HER2
Gene ID 2064
Accession # NM_004448.
Source E. coli
Appearance Liquid
Physical Form Description 0.2 mg/ml in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol
Molecular Weight ~ 100 kDa protein in SDS-PAGE under reducing conditions (aa 676 - end, N terminal-GST tag)
Biological Activity > 20 U/mg
Amino Acid Sequence aa 676 - end
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

HER2 gene encodes a cell-surface glycoprotein tyrosine kinase receptor with extensive homology to the epidermal growth factor receptor. HER2 is an oncogene and overexpression of unaltered HER2 coding sequences in NIH 3T3 cells results in cellular transformation and tumorigenesis. HER2 is amplified in about 30% of primary human breast malignancies and overexpression of HER2 is associated with the most aggressive tumors that show uncontrolled proliferation, resistance to apoptosis and increased motility.


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