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Hemocyanin-Keyhole Limpet (KLH) subunits, solution

Pure KLH ideal for antibody purification and as a carrier protein and immunogen
Catalog #: 6287
$275.00

Product Details

Cat # +Size 6287-20
Size 20 mg
Alternate Name KLH, keyhole limpett hemocyanin, hemocyanin, Megathura crenulata hemocyanin
Gene Symbol KLH
Source Megathura crenulata, Giant keyhole limpet
Appearance Liquid
Physical Form Description 20 mg/ml of clear dark blue liquid which may contain some particulate and fibers.
Molecular Weight 350 and 390 kDa (Two main characteristic bands co-migrating with ferritin)
Purity by SDS-PAGE ≥ 95%
Handling Centrifuge the vial prior to opening.
Storage Conditions 2-8°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Hemocyanins are proteins that use copper binding sites to bind and transport oxygen in a variety of arthropods and mollusks. Hemocyanin is isolated from the hemolymph of the animals. Hemocyanin is one of the strongest antigens known. Hemocyanin has been in use as an immunological reagent for many years. It is used as a carrier protein for antibody production against antigens. Recent advances in immunology and the role immune system plays in diseases have opened a whole new era of product development activities aimed at developing novel therapeutics which is aimed at teaching the body's immune system to fight diseases like cancer, AIDS, etc. The approach involves the use of highly immunogenic molecule like the hemocyanin for non-specific immunostimulation (NSI) or active specific immunostimulation (ASI) using conjugate vaccines, wherein the tumor (disease) specific antigens are covalently bound to carrier protein like KLH and the product used in human clinical studies. Such products are termed “vaccines”. BioVision’s KLH subunits powder has major advantages associated with it, in terms of flexibility of use, the choice of buffer in early developmental studies and avoidance of issues associated with reconstitution of dry powder. These subunits are highly pure and have low endotoxin content.


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