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Hemocyanin-Keyhole Limpet (KLH), Native

Pure KLH ideal for antibody purification and as a carrier protein and immunogen
Catalog #: 6288

Product Details

Cat # +Size 6288-25
Size 25 mg
Alternate Name KLH, keyhole limpett hemocyanin, hemocyanin, Megathura crenulata hemocyanin
Gene Symbol KLH
Source Megathura crenulata, Giant keyhole limpet
Appearance Liquid
Physical Form Description 25 mg in phosphate buffered saline, pH 7.2, containing 1 mM calcium chloride and 0.5 mM magnesium chloride with 15 mM sodium azide as preservative. The liquid may appear faint blue to blue with some haziness due to particulates from the native source.
Molecular Weight 370 kDa (One major band)
Handling Centrifuge the vial prior to opening.
Storage Conditions 2-8°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Hemocyanins are proteins that use copper binding sites to bind and transport oxygen in a variety of arthropods and mollusks. Hemocyanin is isolated from the hemolymph of the animals. Hemocyanin is one of the strongest antigens known. Hemocyanin has been in use as an immunological reagent for many years. It is used as a carrier protein for antibody production against antigens. Recent advances in immunology and the role immune system plays in diseases have opened a whole new era of product development activities aimed at developing novel therapeutics for teaching the body's immune system to fight diseases. The approach involves the use of highly immunogenic molecule like the hemocyanin for non-specific immunostimulation (NSI) or active specific immunostimulation (ASI) using conjugate vaccines, wherein the tumor (disease) specific antigens are covalently bound to carrier protein like KLH and the product used in human clinical studies. BioVision’s native KLH has low endotoxin content and consistent high concentration in a phosphate buffer containing no extraneous metal ions for product stabilization, however with improved stability. This research grade material is suited for use in vaccine product development activities and also for routine immunological studies, antibody production, production of activated KLH and other developmental activities.

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