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HdmX/MDM4 Antibody

Catalog #: 3762
$265.00

Product Details

Cat # +Size 3762-100
Size 100 µl
Antibody Target HdmX/MDM4
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide of human HmdX/MDM4
Accession # O15151
Gene ID 4194
Appearance Colorless liquid
Formulation 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunoprecipitation
Application & Usage Western blotting (1:500 – 1:1500) and Immunoprecipitation. MCF7 cell lysate can be used as a positive control. However, the optimal concentrations should be determined individually. The antibody recognizes the HdmX/MDM4 of human origin. Reactivity to othe
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus. This sequestration of MDMX by ARF results in an increase in p53 transactivation. In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes the level of p73. Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.


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