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HDM-201

A highly potent p53-MDM2 interaction inhibitor
Catalog #: B2459

In stock

SKU-Size Size Price Qty
B2459-1 1 mg
$75.00
B2459-5 5 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name Siremadlin; NVP-HDM 201; (S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl) -1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one
Appearance Crystalline solid
CAS # 1448867-41-1
Molecular Formula C₂₆H₂₄Cl₂N6O₄
Molecular Weight 555.41
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
SMILES CC(C)N1C2=C(C(=O)N(C2C3=CC=C(C=C3)Cl)C4=CC(=CN(C4=O)C)Cl)N=C1C5=CN=C(N=C5OC)OC
InChi InChI=1S/C26H24Cl2N6O4/c1-13(2)33-21-19(30-22(33)17-11-29-26(38-5)31-23(17)37-4)25(36)34(18-10-16(28)12-32(3)24(18) 35)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3/t20-/m0/s1
InChi Key AGBSXNCBIWWLHD-FQEVSTJZSA-N
PubChem CID 71678098
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Siremadlin (NVP-HDM201) is a potent and highly specific MDM-2/p53 inhibitor. It binds to human MDM2 protein with a picomolar Ki value (0.21 nM). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells.


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