HDJ1, human recombinant

Aids in protein folding, transport and assembly
Catalog #: 4899 | abID:

Product Details

Cat # +Size 4899-25
Size 25 μg
Alternate Name HSP-40, HSP40, DnaJ, DNAJB1, HSPF1, Hdj1, DnaJ homolog subfamily B member 1, Heat shock 40 kDa protein 1, Heat shock protein 40, DnaJ protein homolog 1, HDJ-1, Sis1.
Gene Symbol DNJB1
Gene ID 3337
Accession # P25685
Source E. coli
Appearance Liquid
Physical Form Description In 50 mM Tris-HCl, pH 7.7, containing 100 mM potassium chloride
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Hsp40/Hdj1 is a cytosolic co-chaperone belonging to the class DnaJ, named after its homolog in E. coli. Hsp40 functions in protein folding by binding nascent peptides and unfolded substrates and facilitating substrate interaction with Hsp70. Binding of Hsp40 to Hsp70 increases Hsp70 ATP hydrolysis and substrate binding, which is reversed by the action of nucleotide exchange factors (GrpE in E. coli). Repeated cycles of Hsp40/Hsp70 peptide binding and ATP hydrolysis prevent premature folding and aggregation, promoting protein maturation throughout the cell.


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