Product Details
| Antibody Target | HDAC8 |
|---|---|
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide surrounding amino acid 10 of mouse HDAC-8 |
| Accession # | Q8VH37 |
| Gene ID | 70315 |
| Appearance | Colorless liquid |
| Concentration | 0.2 mg/ml |
| Formulation | 100 µg (0.2 mg/ml) protein A purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
| Purification | Affinity purified |
| Species Reactivity | Human |
| Application | Western blotting, Immunoprecipitation, Immunohistochemistry |
| Application & Usage | Western blotting (0.5-4 µg/ml), immunoprecipitation (10-20 µg/ml), and Immunohistochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Mammalian HDAC-8, isolated from human kidney, is a member of the histone deacetylase family. HDAC-8 shares homology with other HDACs in the family, but has different tissue distribution. HDAC-8 is localized to the nucleus and plays a role in the tissue development as well as cancer etiology.
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Mao, X. et. al. The Tricyclic Antidepressant Amitriptyline Inhibits D-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence. Mol. Pharmacol., Apr 2011; 79: 672 - 680.
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