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HDAC6, human recombinant

Regulates the acetylation status of non-histone substrates
Catalog #: 7534
$255.00

Product Details

Cat # +Size 7534-10
Size 10 μg
Alternate Name KIAA0901, JM21, HD6
Gene Symbol HDAC6
Gene ID 10013
Accession # Q9UBN7
Source Baculovirus
Appearance Liquid
Physical Form Description In 50 mM Tris-HCl, pH 8.0, 500 mM NaCl, 50 mM KCl, 2 mM EDTA, 10% glycerol, and 2 mM DTT.
Molecular Weight 159 kDa (N-terminal GST tag)
Purity by SDS-PAGE ≥82%
Endotoxin Level <1 EU/μg by LAL method
Biological Activity 560 pmole/min/μg. Assay conditions: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 20 μM HDAC substrate (Cat # 2396), and HDAC6 (7.8 – 500 ng). Incubation condition: 30 min at 37ºC followed by developing for 15 min at room
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

HDAC6 is a Class II HDAC. It is unique among human HDACs in having two full deacetylase domains. As a tubulin deacetylase, HDAC6 may act to promote autophagic clearing of Huntington aggregates and retard HIV1 infection. It can shuttle between the nucleus and cytoplasm, suggesting potential extra nuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.


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