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HDAC6 Antibody

based on 4 citations in multiple journalsHDAC6 Antibody44.1 4
Catalog #: 3606
SKU-Size Size Price Qty
3606-30T 30 µg
$89.00
3606-100 100 µg
$280.00
More Sizes Get Quote

Product Details

Antibody Target HDAC6
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide mapping to the N-terminus of mouse HDAC-6
Accession # Q9Z2V5
Gene ID 15185
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunohistochemistry
Application & Usage Western blotting (0.5-4 µg/ml) and Immunohistochemistry (20 µg/ml). However, the optimal conditions should be determined individually. The antibody detects ~134 kDa HDAC-6. Jurkat cell lysate can be used as a positive control. The antibody does not cross-
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Human HDAC6 (1215 a.a. residues) possesses two separate putative catalytic domains, both of which are fully functional and contribute independently to the overall activity of HDAC6. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. HDAC6 may participate in coordinating expression of a group of genes involved in the remoldeling of chromatin during cell differentiation.


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Wei, L. H. et. al. Histone Deacetylase 6 Regulates Estrogen Receptor α in Uterine Leiomyoma. Reproductive Sciences, Aug 2011; 18: 755 - 762.
Wei, L. H. et. al. Histone Deacetylase 6 Regulates Estrogen Receptor α in Uterine Leiomyoma. Reproductive Sciences, Aug 2011; 18: 755 - 762.
Mao, X. et. al. The Tricyclic Antidepressant Amitriptyline Inhibits D-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence. Mol. Pharmacol., Apr 2011; 79: 672 - 680.
Wang, L., et al. (2005) PNAS 102: 9394-9399. (Immunofluorescence)
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