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HDAC2 Antibody

based on 3 citations in multiple journalsHDAC2 Antibody34.1 4
Catalog #: 3602
SKU-Size Size Price Qty
3602-30T 30 µg
$89.00
3602-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target HDAC2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 479 of human HDAC2
Accession # EAW48255
Gene ID 3066
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2 mg/ml) affinity purified rabbit anti-HDAC2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat, chicken, hamster, dog
Application Western blot, Immunocytochemistry
Application & Usage Western blotting (0.5-4 µg/ml) and immunocytochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 55 kDa Histone Deacetylase 2 in samples from human, mouse, rat, chicken, hamster, and canine orig
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

HDAC2 is a class I mammalian histone deacetylase containing 488 amino acid residues with an apparent size of ~55 kDa by denaturing SDS-PAGE. HDAC2 has been shown to interact directly with transcription repressor complexes and the nuclear receptor corepressor N-CoR.


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Chen at al., Estradiol Inhibits Th17 Cell Differentiation through Inhibition of RORDescription: {gamma}T Transcription by Recruiting the ERα/REA Complex to Estrogen Response Elements of the RORDescription: {gamma}T Promoter. J. Immunol., Apr 2015; 194: 4019 - 4028.
Cao et al., The Antiparasitic Clioquinol Induces Apoptosis in Leukemia and Myeloma Cells by Inhibiting Histone Deacetylase Activity. J. Biol. Chem., Nov 2013; 288: 34181 - 34189.
Mao, X. et. al. The Tricyclic Antidepressant Amitriptyline Inhibits D-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence. Mol. Pharmacol., Apr 2011; 79: 672 - 680.
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