Product Details
| Antibody Target | HDAC2 |
|---|---|
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide surrounding amino acid 479 of human HDAC2 |
| Accession # | EAW48255 |
| Gene ID | 3066 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 0.5 mg/ml affinity purified rabbit anti-HDAC2 polyclonal antibody in PBS, pH 7.2, 30% glycerol, 0.5% BSA, 0.5 mM EDTA and 0.03% proclin |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat, chicken, hamster, dog |
| Application | Western blot, Immunocytochemistry |
| Application & Usage | Western blotting (0.5-4 µg/ml) and immunocytochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 55 kDa Histone Deacetylase 2 in samples from human, mouse, rat, chicken, hamster, and canine orig |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
HDAC2 is a class I mammalian histone deacetylase containing 488 amino acid residues with an apparent size of ~55 kDa by denaturing SDS-PAGE. HDAC2 has been shown to interact directly with transcription repressor complexes and the nuclear receptor corepressor N-CoR.
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Chen at al., Estradiol Inhibits Th17 Cell Differentiation through Inhibition of ROR
T Transcription by Recruiting the ERα/REA Complex to Estrogen Response Elements of the ROR
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T Transcription by Recruiting the ERα/REA Complex to Estrogen Response Elements of the RORT Promoter. J. Immunol., Apr 2015; 194: 4019 - 4028.Cao et al., The Antiparasitic Clioquinol Induces Apoptosis in Leukemia and Myeloma Cells by Inhibiting Histone Deacetylase Activity. J. Biol. Chem., Nov 2013; 288: 34181 - 34189.
Mao, X. et. al. The Tricyclic Antidepressant Amitriptyline Inhibits D-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence. Mol. Pharmacol., Apr 2011; 79: 672 - 680.
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