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HDAC1 Antibody

based on 2 citations in multiple journalsHDAC1 Antibody24.1 4
Catalog #: 3601
SKU-Size Size Price Qty
3601-30T 30 µg
$89.00
3601-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target HDAC1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to the C-terminus of human HDAC1
Accession # NP_004955
Gene ID 3065
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) peptide affinity purified rabbit anti-HDAC1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blotting, Immunoprecipitation, Immunohistochemistry
Application & Usage Western blotting (0.5-4 µg/ml), Immunoprecipitation (10-20 µg/ml), and Immunohistochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually. The antibody detects the 62 kDa histone deacetylase 1. It does not cross-react wi
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

HDAC1 is an active component of transcriptional corepressor complexes which can be recruited to specific promoter regions via transcriptional factors. HDAC1 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, which leads to the inhibition of gene transcription.


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Chen at al., Estradiol Inhibits Th17 Cell Differentiation through Inhibition of RORDescription: {gamma}T Transcription by Recruiting the ERα/REA Complex to Estrogen Response Elements of the RORDescription: {gamma}T Promoter. J. Immunol., Apr 2015; 194: 4019 - 4028.
Cao et al., The Antiparasitic Clioquinol Induces Apoptosis in Leukemia and Myeloma Cells by Inhibiting Histone Deacetylase Activity. J. Biol. Chem., Nov 2013; 288: 34181 - 34189.
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