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HDAC-8, human recombinant

Critical regulator of transcription, cell cycle progression, and developmental events
Catalog #: 7618
SKU-Size Size Price Qty
7618-20 20 μg
$195.00
7618-100 100 μg
$495.00
7618-1000 1 mg
$3,950.00
More Sizes Get Quote

Product Details

Alternate Name HDAC-8,HDACL1, Histone deacetylase 8
Gene Symbol HDAC8
Gene ID 55869
Accession # Q9BY41
Source Sf9 insect cells
Appearance Liquid
Physical Form Description Liquid in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol.
Molecular Weight 44 kDa
Purity by SDS-PAGE ≥90%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).


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