HDAC-3, Human Recombinant

A potential tumor suppressor gene
Catalog #: 7613 | abID:

Product Details

Alternate Name Histone deacetylase 3, HD3, RPD3-2, SMAP45
Gene Symbol HDAC3
Gene ID 8841
Accession # O15379
Source Sf9 insect cells
Appearance Liquid
Physical Form Description rh-HDAC-3 is supplied with N-term His-tag as a liquid in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol.
Molecular Weight 51.1kDa
Purity by SDS-PAGE ≥50%
Application and Usage Active HDAC3 is useful in studying enzyme regulation, determining target substrates, screening deacetylase inhibitors, or as a positive control in HDAC activity assays. We recommend using 1-5 µU/assay for analyzing HDAC3 activity.
Specific Activity ≥ 0.5 µU/µl
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


Human Histone Deacetylase 3 (HDAC3) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Like other class I and II HDAC members, the activity of HDAC3 is sensitive to HDAC inhibitor Trichostatin A (TSA).

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