Product Details
| Alternate Name | Histone deacetylase 3, HD3, RPD3-2, SMAP45 |
|---|---|
| Gene Symbol | HDAC3 |
| Gene ID | 8841 |
| Accession # | O15379 |
| Source | Sf9 insect cells |
| Appearance | Liquid |
| Physical Form Description | rh-HDAC-3 is supplied with N-term His-tag as a liquid in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol. |
| Molecular Weight | 51.1kDa |
| Purity by SDS-PAGE | ≥50% |
| Application and Usage | Active HDAC3 is useful in studying enzyme regulation, determining target substrates, screening deacetylase inhibitors, or as a positive control in HDAC activity assays. We recommend using 1-5 µU/assay for analyzing HDAC3 activity. |
| Specific Activity | ≥ 0.5 µU/µl |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Human Histone Deacetylase 3 (HDAC3) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Like other class I and II HDAC members, the activity of HDAC3 is sensitive to HDAC inhibitor Trichostatin A (TSA).
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