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Harmine

A MAO-A and DYRK inhibitor
Catalog #: 2561
SKU-Size Size Price Qty
2561-50 50 mg
$75.00
2561-250 250 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
Appearance White to off-white solid
CAS # 442-51-3
Molecular Formula C₁₃H₁₂N₂O
Molecular Weight 212.25
Purity ≥98% by titration
Solubility DMSO (>20 mg/ml)
SMILES CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
InChi InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChi Key BXNJHAXVSOCGBA-UHFFFAOYSA-N
PubChem CID 5280953
MDL Number MFCD00004958
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC₅₀’s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 µM; DYRK4 = 80 µM). Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells(GSLC’s) possibly via inhibition of Akt phosphorylation. Selective competitive and reversible inhibitor of MAO-A (IC₅₀ = 8 µM). Also regulates PPARγ expression and displays antidiabetic activity.


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