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Product Details
| Alternate Name | 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 442-51-3 |
| Molecular Formula | C₁₃H₁₂N₂O |
| Molecular Weight | 212.25 |
| Purity | ≥98% by titration |
| Solubility | DMSO (>20 mg/ml) |
| SMILES | CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC |
| InChi | InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 |
| InChi Key | BXNJHAXVSOCGBA-UHFFFAOYSA-N |
| PubChem CID | 5280953 |
| MDL Number | MFCD00004958 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC₅₀’s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 µM; DYRK4 = 80 µM). Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells(GSLC’s) possibly via inhibition of Akt phosphorylation. Selective competitive and reversible inhibitor of MAO-A (IC₅₀ = 8 µM). Also regulates PPARγ expression and displays antidiabetic activity.
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