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H3K23ac polyclonal antibody

Polyclonal Antibody to detect H3K23ac in human samples.
Catalog #: 6868

In stock

$245.00

Product Details

Cat # +Size 6868-50
Size 50 μl
Antibody Target H3K23ac
Alternate Name Histone 3
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Polyclonal antibody raised in rabbit against histone H3 containing the acetylated lysine 23 (H3K23ac), using a KLH-conjugated synthetic peptide.
Accession # P68431
Gene ID 8350
Appearance Colorless liquid
Formulation In PBS with 0.05% (W/V) sodium azide.
Purification Whole Anti-Sera
Species Reactivity Human.
Application Western blot, ELISA, Dot Blot.
Positive Control Western blot: HeLa cells, ELISA: Antigen, Dot blot: Histone Peptides.
Application & Usage WB: 1:250, ELISA: 1:100 – 1:500, Dot Blot: 1:1,000.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called “histone code”. Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. Acetylation of histone is associated with gene activation.


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