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Product Details
| Alternate Name | N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-Isoquinolinesulfonamide dihydrochloride |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 127243-85-0 |
| Molecular Formula | C₂₀H₂₀BrN₃O₂S.2HCl |
| Molecular Weight | 519.28 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (200 mg/ml) and H₂O (25 mg/ml) |
| SMILES | C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNCC=CC3=CC=C(C=C3)Br.Cl.Cl |
| InChi | InChI=1S/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;; |
| InChi Key | GELOGQJVGPIKAM-WTVBWJGASA-N |
| PubChem CID | 5702541 |
| MDL Number | MFCD11045926 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A cell-permeable, ATP-competitive inhibitor of Protein Kinase A (PKA) (IC₅₀ = 50 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII with IC₅₀ values of 120 nM, 80 nM and 270 nM respectively.
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