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H-89 Dihydrochloride

A protein kinase A (PKA) inhibitor
Catalog #: 1768
SKU-Size Size Price Qty
1768-1 1 mg
1768-5 5 mg
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Product Details

Alternate Name N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-Isoquinolinesulfonamide dihydrochloride
Appearance White to off-white solid
CAS # 127243-85-0
Molecular Formula C₂₀H₂₀BrN₃O₂S.2HCl
Molecular Weight 519.28
Purity ≥98% by HPLC
Solubility DMSO (200 mg/ml) and H₂O (25 mg/ml)
InChi InChI=1S/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;;
PubChem CID 5702541
MDL Number MFCD11045926
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A cell-permeable, ATP-competitive inhibitor of Protein Kinase A (PKA) (IC₅₀ = 50 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII with IC₅₀ values of 120 nM, 80 nM and 270 nM respectively.

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