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A potent and selective transforming growth factor beta receptor I (TGF-βR1) inhibitor
Catalog #: 2820
SKU-Size Size Price Qty
2820-10 10 mg
2820-50 50 mg
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Product Details

Alternate Name 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide
Appearance Off-white solid
CAS # 452342-67-5
Molecular Formula C₂₅H₂₃N₅O₂
Molecular Weight 425.48
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
InChi InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)
PubChem CID 10202642
MDL Number MFCD20527321
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GW788388 is a potent and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5) (IC₅₀ = 18 nM). Also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.

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