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Product Details
| Alternate Name | (2-Methyl-4-(((4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazol-5-yl)methyl)sulfanyl)phenoxy)acetic acid |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 317318-70-0 |
| Molecular Formula | C₂₁H₁₈F₃NO₃S₂ |
| Molecular Weight | 453.5 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (50 mg/ml) or EtOH (12 mg/ml) |
| SMILES | CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O |
| InChi | InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27) |
| InChi Key | YDBLKRPLXZNVNB-UHFFFAOYSA-N |
| PubChem CID | 9803963 |
| MDL Number | MFCD09033000 |
| Handling | Protect from light and air |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A selective agonist for PPARδ (peroxisome proliferator-activated receptorδ) (EC₅₀ = 1. 1 nM), displaying 1000-fold selectivity over the other human subtypes. In macrophages, fibroblasts, and intestinal cells, GW501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux.
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