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GW501516

A selective agonist for PPARδ
Catalog #: 1971

In stock

SKU-Size Size Price Qty
1971-1 1 mg
$90.00
1971-5 5 mg
$365.00
More Sizes Get Quote

Product Details

Alternate Name (2-Methyl-4-(((4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazol-5-yl)methyl)sulfanyl)phenoxy)acetic acid
Appearance White to off-white solid
CAS # 317318-70-0
Molecular Formula C₂₁H₁₈F₃NO₃S₂
Molecular Weight 453.5
Purity ≥98% by HPLC
Solubility DMSO (50 mg/ml) or EtOH (12 mg/ml)
SMILES CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O
InChi InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
InChi Key YDBLKRPLXZNVNB-UHFFFAOYSA-N
PubChem CID 9803963
MDL Number MFCD09033000
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A selective agonist for PPARδ (peroxisome proliferator-activated receptorδ) (EC₅₀ = 1. 1 nM), displaying 1000-fold selectivity over the other human subtypes. In macrophages, fibroblasts, and intestinal cells, GW501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux.


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