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GW-806742X

A potent MLKL inhibitor
Catalog #: B3246
SKU-Size Size Price Qty
B3246-5 5 mg
$95.00
B3246-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name GW806742X; 3-(4-(Methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-ylamino)benzenesulfonamide
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 579515-63-2
Molecular Formula C₂₅H₂₂F₃N₇O₄S
Molecular Weight 573.55
Purity ≥98% by HPLC
Solubility ~2 mg/ml DMSO
SMILES CN(C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)OC(F)(F)F)C3=NC(=NC=C3)NC4=CC(=CC=C4)S(=O)(=O)N
InChi InChI=1S/C25H22F3N7O4S/c1-35(22-13-14-30-23(34-22)31-18-3-2-4-21(15-18)40(29,37)38)19-9-5-16(6-10-19)32-24(36)33-17-7-11-20(12-8-17)39-25(26,27)28/h2-15H,1H3,(H2,29,37,38)(H,30,31,34)(H2,32,33,36)
InChi Key SNRUTMWCDZHKKM-UHFFFAOYSA-N
PubChem CID 5329829
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GW-806742X is a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, as well as a human and murine necroptosis inhibitor. GW806742X binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and displays anti-necroptosis activity. GW806742X blocks necroptosis and IL-33 release in vitro and reduces eosinophilia in Aspergillus fumigatus extract-induced asthma in vivo, an allergic inflammation model that is highly dependent on IL-33.


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