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GW-441756

A potent and specific inhibitor of Trk A
Catalog #: B1147
SKU-Size Size Price Qty
B1147-5 5 mg
$135.00
B1147-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Appearance Red Solid
CAS # 504433-23-2
Molecular Formula C₁₇H₁₃N₃O
Molecular Weight 275.31
Purity ≥98% by HPLC
Solubility DMSO (~4 mg/ml)
SMILES CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC=N4)NC3=O
InChi 1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-
InChi Key NXNQLECPAXXYTR-LCYFTJDESA-N
PubChem CID 9943465
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GW-441756 is potent and specific inhibitor of Trk A (tropomyosin-related kinase A) tyrosine kinase (IC₅₀ = 2 nM). This inhibition of TrkA reduces cell proliferation and enhances the effects of chemotherapeutic agents in sarcoma. GW-441756 displays >100-fold selectivity over a range of other kinases.


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