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based on 1 citations in multiple journalsGW-78603414.1 4
A potent and selective multi-targeted tyrosine kinase inhibitor
Catalog #: 1916
SKU-Size Size Price Qty
1916-5 5 mg
1916-25 25 mg
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Product Details

Appearance White to off-white solid
CAS # 444731-52-6
Molecular Formula C₂₁H₂₃N₇O₂S
Molecular Weight 437.52
Purity ≥98% by HPLC
Solubility DMSO (~ 8 mg/ml)
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
InChi InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
PubChem CID 10113978
MDL Number MFCD11616589
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor and c-kit, key proteins responsible for tumor growth and angiogenesis.

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Crispin T. Hiley et al., Vascular Endothelial Growth Factor A Promotes Vaccinia Virus Entry into Host Cells via Activation of the Akt Pathway. J. Virol., Mar 2013; 87: 2781 - 2790.
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