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A potent PPARα antagonist
Catalog #: 9453
SKU-Size Size Price Qty
9453-1 1 mg
9453-5 5 mg
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Product Details

Alternate Name N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide
Appearance Cream-colored solid
CAS # 880635-03-0
Molecular Formula C₃₅H₃₆F₃N₃O₄
Molecular Weight 619.67
Purity ≥98%
Solubility DMSO (~40 mg/ml) or EtOH (~10 mg/ml)
InChi InChI=1S/C35H36F3N3O4/c1-4-33(43)39-22-29(40-23(2)20-32(42)26-12-14-28(15-13-26)35(36,37)38)21-25-10-16-30(17-11-25)44-19-18-31-24(3)45-34(41-31)27-8-6-5-7-9-27/h5-17,20,29,40H,4,18-19,21-22H2,1-3H3,(H,39,43)/b23-20-/t29-/m0/s1
PubChem CID 446738
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GW-6471 is a potent PPARα antagonist (IC₅₀ = 240 nM). It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor. GW-6471 significantly prevents cardiomyocyte differentiation and results in the reduced expression of cardiac sarcomeric proteins and specific genes in a time-dependent manner.

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