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A c-RAF1 kinase inhibitor
Catalog #: 2412
SKU-Size Size Price Qty
2412-5 5 mg
2412-25 25 mg
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Product Details

Alternate Name 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one
Appearance Dark orange solid
CAS # 220904-83-6
Molecular Formula C₁₅H₈Br₂INO₂
Molecular Weight 520.95
Purity ≥98% by TLC
Solubility DMSO (~50 mg/ml)
SMILES C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2
InChi InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
PubChem CID 5924208
MDL Number MFCD03453076
Handling Protect from light and air
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent inhibitor of cRAF1 kinase (IC₅₀ = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling.

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