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A potent and selective, non-steroidal farnesoid X receptor (FXR) agonist
Catalog #: B2278
SKU-Size Size Price Qty
B2278-5 5 mg
B2278-25 25 mg
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Product Details

Alternate Name 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid
Appearance White solid
CAS # 278779-30-9
Molecular Formula C₂₈H₂₂Cl₃NO₄
Molecular Weight 542.84
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
InChi InChI=1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)
PubChem CID 9893571
MDL Number MFCD09971006
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GW-4064 is a potent and selective, non-steroidal farnesoid X receptor (FXR) agonist (EC₅₀ = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes.

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